A social experiment entitled "A Day Without Wikipedia" has commenced, and for the most part everyone is handling it like big kids, except for folks from the RIAA, who've chosen to behave like babydicks.
Lots of sites have joined Wikipedia in blacking out to protest SOPA and PIPA, and Sopastrike.com has a list. Here are the sites whose temporary absences are least likely to have any real impact on your life UNLESS ...
... you're a nerd.
In which case, you're really bummed that Minecraft is participating in the protest.
... you actually still think LOLcats are funny.
Icanhascheezeburger.com is on hiatus.
... you're a one of these:

... you're one of these:

... you're lonely.
Dating-slash-penpallery site Bepenfriends.com is down for the day.
... you graduated from Secaucus High School in 2011.
This girl's Facebook page is blacked-out, guys.
Showing 1-7 of 7
i'm a nerd. at least they didn't shut down the central login server
this is great though
http://www.buzzfeed.com/jpmoore/25-angry-k…
Least likely to "effect" my life? Undoubtedly so, as the solitary incident that effected my life occurred while my parents were humping at what I think of as my own personal "big bang".
If you meant "affect", then it's an entirely different story.